Gene expression signatures indicate loss of function by master regulators of the genome

Second only to the notorious TP53 gene, the genes for assemblages known as mSWI/SNF protein complexes are the most frequently mutated entities in cancer cells. Made up of 10 to 15 subunits, the complexes are built from the activity of 29 individual genes.

source https://medicalxpress.com/news/2023-04-gene-signatures-loss-function-master.html