Stress granules may drive obesity-associated pancreatic cancer

Obesity is a known risk factor for at least 13 types of cancer, in part because it creates ever-present inflammatory state. For years, one researcher has wondered if there's more to the story than inflammation. New research from the lab of Dr. Elda Grabocka shows a new way that obesity may drive cancer formation in pancreatic cancer, which has a five-year survival of 11% for the majority of patients. In a study published in Cancer Discovery, the researchers found that stress granules are much more abundant in obesity-related pancreatic cancer compared to non-obese patients, and importantly, blocking their formation stopped cancer growth in animals. The research reveals a new direction for developing cancer therapy.

source https://medicalxpress.com/news/2022-09-stress-granules-obesity-associated-pancreatic-cancer.html