Cell by cell, scientists are building a high-resolution map of brain changes in Alzheimer's disease

If you compare the brain of someone who has died from neurodegenerative disease to that of a healthy person, you can't miss the difference: In the case of severe Alzheimer's, the brain will be noticeably smaller, with large gaps where pieces would normally nestle close together.

source https://medicalxpress.com/news/2022-07-cell-scientists-high-resolution-brain-alzheimer.html