Tumor cells activate DNA breaks, protecting them from death due to treatment-induced damage

An international team of researchers has found that some tumor cells are able to set off a caspase-activated DNAse (CAD) that promotes breaks in DNA strands after exposure to genotoxic treatments. In their paper published in the journal Science, the group suggests the broken strands help the tumors overcome the treatment by preventing their own cell death.

source https://medicalxpress.com/news/2022-04-tumor-cells-dna-death-due.html