GABA released by B-cells blunts the immune response to tumors

A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted by the B-cells promoted the emergence of anti-inflammatory macrophages, blunting the body's cytotoxic T-cell-based response to tumors. According to the authors, this work, published in Nature, could lead to the development of therapies that work to fine tune the immune response.

source https://medicalxpress.com/news/2021-11-gaba-b-cells-blunts-immune-response.html