An autoimmune disorder may underlie male infertility

Investigators have found that the absence of autoimmune regulator (Aire) in mice results in fertility problems similar to those affecting men with autoimmune polyendocrine syndrome type I (APS-1). Aire-dependent central tolerance plays a critical role in maintaining male fertility by preventing autoimmune attack against multiple reproductive targets, they report in the American Journal of Pathology.

source https://medicalxpress.com/news/2021-08-autoimmune-disorder-underlie-male-infertility.html